patients who have high expression of this target, which is not uncommon in ovarian cancer-even probably around the 50% range-there's a targeted agent.

This includes things like upifitamab rilsodotin, which is an antibody-drug conjugate targeting NaPi2b. But there are other targets that are being explored. Mirvetuximab soravtansine-gynx (Elahere) is going to help advance that field. Salani also spoke about gemogenovatucel-T, which she described as being a potential maintenance therapy option for patients with homologous repair proficient (HRP) disease that may not require PARP inhibitors as supplemental treatment.įor ovarian cancer, we continue to have struggles in the platinum-resistance setting. According to Salani, upifitamab rilsodotin may also benefit patients as maintenance therapy following treatment for platinum-sensitive disease. Salani, the Gynecologic Oncology Fellowship Director at University of California Los Angeles Health and the Gynecologic Oncology editorial board member for the journal ONCOLOGY ®, highlighted upifitamab rilsodotin’s capability of targeting NaPi2b, a target commonly expressed in platinum-resistant ovarian cancer. In the UK, five people die with sepsis every hour.Following the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting,Ritu Salani, MD, discussed two potential treatments for patients with platinum-resistant ovarian cancer, including targeted agent upifitamab rilsodotin (XMT-1536) and autologous tumor vaccine gemogenovatucel-T (Virgil), that warrant future research. It is not known why some people develop sepsis in response to these common infections whereas others don’t. Sepsis always starts with an infection, and can be triggered by any infection including chest infections and UTIs. Sepsis is indiscriminate: while it primarily affects very young children and older adults, and is also more common in people with underlying health conditions, it can sometimes be triggered in those who are otherwise fit and healthy. It can lead to shock, multiple organ failure and sometimes death, especially if not recognised early and treated promptly. It occurs when the body’s immune system – which normally helps to protect us and fight infection – goes into overdrive. SEPSIS is a life-threatening condition that arises when the body’s response to an infection injures its own tissues and organs.

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